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Dr. Fazal Adnan
Assistant Professor
Industrial Biotechnology

ASAB
National University of Sciences and Technology (NUST)
H-12 Islamabad
Tel : +92 51 9085 6142 Cell# +92 333 3122939

Specialization
Bacterial gene expression and regulation, RNA biology, RNomics

Education
Ph.D Molecular Microbiology (University of Giessen, Germany)

​Dr. Fazal Adnan is serving as Assistant Professor at the Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST) since July 2015. He aquired his bachelor’s degree in biotechnology from the University of Peshawar in 2006 and his MPhil in Industrial Biotechnology from the Govt. College University (GCU) Lahore in 2009. After serving the Centre of Excellence in Molecular Biology (CEMB) Lahore, for one year as a Research Officer, he was awarded with the prestigious DAAD scholarship by the German academic exchange services for his PhD studies at the University of Giessen in Germany. During his stay at the Institute of Molecular Microbiology in Giessen, he investigated role of protein and RNA-based regulators in the photooxidative ​stress response mechanisms of alpha-proteobacteria Rhodobacter sphaeroides.
​​
Living cells have the luxury to produce a bulk of transcripts but not all of these transcripts get a chance to be translated into their corresponding proteins. The bacterial cell is considered very effective in using its genetic material for making exact products in balanced level and at the right time. This ability of a cell to control rate and manner of the gene expression is known as gene regulation. This regulated process is dependent on a complex set of regulatory proteins, RNA molecules and other metabolites, which not only determine the earlier production but also the latter fate of a transcript produced.
In bacteria, non-coding RNAs adopt various ways to regulate mRNA and protein levels of many genes. There are multiple benefits which cells enjoy while employing sRNAs as regulators instead of protein regulators e.g. production of sRNAs is much cheaper and faster compared to production of protein regulators. So we are investigating for the novel non-coding RNAs (natural and synthetic) which are proved to be regulator of the potential target genes, important in various metabolic processes of the bacterial machinery. Some of the major areas of our research is going to be:
 
 
•    Gene silencing via synthetic non-coding RNA in Staphylococcus aureus 
•    Molecular characterisation of novel sRNAs in other bacteria
•    Metabolic re-arrangements for enhanced expression of industrially important genes
•    Phage engineering to use them as alternative to antibiotics
 
Adnan, F., L. Weber and G. Klug, (2015) The sRNA SorY confers resistance during photooxidative stress by affecting a metabolite transporter in Rhodobacter sphaeroides. RNA biology 12:5, 569-577.

Nuss, A.M., F. Adnan, L. Weber, B.A. Berghoff, J. Glaeser & G. Klug, (2013) DegS and RseP homologous proteases are involved in singlet oxygen dependent activation of RpoE in Rhodobacter sphaeroides. PloS one 8: e79520.

I. Haq*, S. Ali, M.M. Javed, A. Saleem, F. Adnan and M.A. Qadeer (2010) IIB GCU, Pakistan. Production of alpha amylase from a randomly induced Bacillus amyloliquefaciens and its application as a desizer in textile industry, Pak. J. Bot., 42(1): 473-484

I. Haq*, M.M. Javed, and F. Adnan (2010) IIB GCU, Pakistan. Kinetics & thermodynamic studies of alpha amylase from Bacillus licheniformis mutant. Pak. J. Bot., 42(5)


Conference Talks/ Posters

Adnan F., Nuss A., Berghoff B, and Klug G. Proteases with a putative role in the singlet    oxygen stress response of phototropic bacterium R. sphaeroides. 6th Annual Conference of the Giessen Graduate School for Life Sciences (GGL), Germany, 09/11-12/2013. (Oral talk)

Adnan F., Nuss A, and Klug G. Activation of RpoE by ChrR proteolysis in the 1O2 stress response of Rhodobacter sphaeroides. Annual Conference of the International Network for the Postgraduate Students (IPID) Koln, May 3-5, 2013. (Oral talk) 

Adnan F., Nuss A., Berghoff B, and Klug G. Activation of RpoE by ChrR proteolysis in the photooxidative stress response of Rhodobacter sphaeroides. 5th Annual Conference of the Giessen Graduate School for Life Sciences (GGL), Germany, 09/18-19/2012. (Poster)

Adnan F., Nuss A., J Glaeser, and G. Klug Activation of RpoE by ChrR proteolysis in the photooxidative stress response of Rhodobacter sphaeroides. Annual Conference of the Association for General and Applied Microbiology (VAAM) Karlsruhe, Apr 3, 2011 to Apr 6, 2011. (Poster) 



Teaching following enlisted courses

UG 
•  Bacteriophages &  Phage Therapy   
PG 
•    Mammalian Cell Processing