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Dr. Nasir Jalal
Assistant Professor
Healthcare Biotechnology

National University of Sciences and Technology (NUST)
H-12 Sector, Islamabad, Pakistan 44000
Tel : +92-051-9085-6130

Radiation Biology and Radiation Carcinogenesis

PhD Cell and Molecular Biology (Colorado State University, Fort Collins, Colorado, USA)

Dr. Nasir Jalal is an assistant professor at the Atta-ur-Rahman School of Applied Biosciences (ASAB) of the National University of Sciences and Technology (NUST) since August 2012. Having been funded by the Fulbright foundation he graduated from the Colorado State University, Fort Collins, USA in July 2012. He returned to his Home Country, Pakistan to fulfill his legal and moral obligations. During his PhD in Cell and Molecular Biology he worked on a Cancer Gap 3 project funded by NASA in preparation for the manned mars mission and was engaged in investigating the effects of deep space heavy ion radiations on human DNA in the laboratory of Dr. Howard L. Liber (a Harvard Medical School graduate). The research was mainly focused on the DNA damage and repair processes that occur as a result of radiation targeting. On Earth this research has applications in cancers and radiotherapy. Because of this research experience he decided to submit research grants that focus on the incidence of liver, colon and breast cancers in Pakistani population. He is currently engaged in research at ASAB/NUST to investigate the role of a DNA repair protein “Artemis” and also on the collection of colon and breast cancer samples to investigate the in-vivo existence of a “bystander effect” that may lead to secondary tumors in people who opt for radiotherapy. He is currently working on two research grants to develop National and International research collaborations. He is a member of the American Association of Cancer Research (AACR) and the Radiation Research Society (RRS).
During his PhD he learned the skill to generate and deduce large chunks of data from his biomedical research and apply statistical analysis to understand molecular processes within a human cell. He took two courses in NIH and NSF styled grant writing, which he is fully employing within Pakistan. During his five month employment at NUST he has published one research paper and submitted three research grants. Three of his publications are in the pipeline and hopes to complete them by June 2013. Dr. Jalal established the role of non-radioactive DNA damage in bystander mutagenesis which has implication in radiotheraputic doses commonly used for cancer treatment.
He has represented ASAB/NUST at the Asian Institute of Technology (Bangkok, Thailand) and was part of an eight member delegation to visit various local industries with the objective to offer indigenous solutions for industrial problems and to bridge the long-standing gap between Industry and academia.
As part of my PhD research (at Colorado State University, 2007-2012) I worked on a project funded by NASA in preparation for the manned MARS mission which gave me the opportunity to explore the effects of deep space heavy ion radiations on human lymphoblastoid cell lines. The particular area of this investigation was based on a phenomenon known as “bystander effect”. For over 20 years this phenomenon has been associated with radiations but my, yet to be published, data provided evidence that non-radioactive sources of DNA damage can also cause bystander signaling. At the National University of Sciences and Technology, my research interests have grown to the investigation of bystander signaling in vivo. This perspective has importance because radiotherapeutic doses may inadvertently trigger secondary tumorigenesis through bystander signaling. My lab is working on collecting samples of breast and colon cancers from participating radiotherapy volunteers and to analyze their excised tumor masses (with their consent) for upregulation of mutation fractions and DNA damage as positive indicators of bystander effect.
As a side project the lab is also involved in investigating the role of Artemis protein in uncapping of telomeres in TK6 cell lines and Artemis deficient cell line CJ179.
Saeed U., Jalal N. and Ashraf M., (2012) Roles of Cyclin Dependent Kinase and CDK-Activating Kinase in cell cycle regulation: A Review of Intracellular Interactions and Functional
Characterization. GJMR Volume 12 Issue 11 Version 1.0 (ISI indexed) In Press.

Jalal, N., (2012) DNA strand break associated bystander effect (DSB-ABE) is linked to gene mutations in naïve cells and indicates the involvement of a MAPK pathway. (PhD thesis/ Pro Quest UMI publishing)

Aurangzeb M., Jalal N., Kauser T., (1997) Isolation of cellulolytic fungi from indigenous sources and shake flask studies on their nutritional requirements for enzyme production. Biologia 1997 43 (1) PP: 113-119 ISSN 0006 3096, September 1, 1997.
Post-graduate level: Cell Cycle Regulation, Human Health and Disease

His research can be utilized in Healthcare Biotechnolog related industries.