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Dr. Mehak Rafiq
Assistant Professor
Healthcare Biotechnology

National University of Sciences and Technology (NUST)
Atta-ur-Rahman School of Applied Biosciences
Tel : +92 51 9085 6169

Computational Proteomics and Cancer Genetics

PhD Cell Biology (University of Greenwich, UK)

My prior experience of research is based in microbiology, cell and molecular biology and cancer genetics. My research utilizes Dictyostelium discoideum as a biomedical model to investigate protein function and determine conservation of pathways across different organisms.
Research Interests:
Cancer Cell Metabolism: Understanding the role of Glycolysis 
Regulation of mitochondria by proteolysis
Mitochondrial tumour suppressors
Tracking the role of rhomboids in Dictyostelium chemotaxis 
Structural controls of urokinase-like receptor and variations introduced by boronic acid binding
Using Dictyostelium as a model organism to test novel drugs

April 2015  "Regulation of mitochondria by proteolysis" - SGM Annual Conference 2015, Birmingham, UK (Invited Talk)
Dec 2014 – "Tracking the role of rhomboids in Dictyostelium chemotaxis" - UK/EU Dictyostelium Meeting, Oxford, UK
Aug 2014 – "Rhomboids and their role in the development of Dictyostelium" - International Dictyostelium Conference, Potsdam, Germany
Dec 2013 – "Rhomboids and their role in Dictyostelium development" - UK/EU Dictyostelium Meeting, MRC-LMB, Cambridge, UK
April 2013 – "The novel 'rhomboid' membrane proteases have developmental and signalling roles in Dictyostelium" -South-eastern Dictyostelium meeting, Royal Holloway University, UK

2016 – HEC SRGP 0.3 Million PKR
2014 - British Society of Cell Biology Travel Grant: Award of £370 given to present in UK/EU. Dictyostelium conference (Oxford, UK) 2014
2014 - Biochemical Society Travel Grant: Award of £400 given to present in a Intl. Dictyostelium conference (Potsdam, Germany) 2014
2014 - Royal Society of Chemistry Travel Grant: Award of £200 given to present in an Intl. Dictyostelium conference (Potsdam, Germany) 2014
2013 – SGM Travel Grant: Award of £200 given to present in a UK Dictyostelium Conference (Cambridge, UK) 2013
Rafiq, M., and Thompson, E., “The shape-shifting superhero: Dictyostelium discoideum.” Microbiology Today 02/2014; 41(1):16-19. 

Rafiq, M., Traynor, D., and Thompson, E. “Proteolytic regulation in Dictoystelium mitochondria.” Annual International Dictyostelium conference; 08/2015

Rafiq, M., Traynor, D., and Thompson, E. “Investigating 'rhomboid' membrane proteases' roles in development and signalling.” Annual International Dictyostelium conference; 08/2013

Rafiq, M., Traynor, D., and Thompson, E. “Investigating the role of rhomboid proteases in the development of Dictyostelium discoideum.” Society of Microbiology (Autumn Conference 2013); 09/2013

Rafiq, M., Spencer, J., and Thompson, E. “Dictyostelium discoideum: a model for testing novel inhibitors of urokinase-type plasminogen activator.” Society of General Microbiology (Autumn Conference 2013), Brighton; 09/2013

Prabhakar, A., Thompson, E., and Rafiq, M., “Dictyostelium discoideum model for drug screening: Mitochondrial aspects.” Society for General Microbiology, Warwick; 09/2012

Rafiq, M., Bateman, C., Prabhakar, A., Glover, B., and Thompson, E., “Rhomboids and communication.” Medway Comprehensive Local Research Network Joint Research Day, Medway Chatham Kent; 04/2012
CSE-883 Data Analysis and Statistics 
CSE-953 Advance Computational Biology
CSE-895 Microarray and RNA Sequencing 
BIO-204 Human Biology & Pathology